[HTML][HTML] Genetic differences in the Chlamydia trachomatis tryptophan synthase α-subunit can explain variations in serovar pathogenesis
AC Shaw, G Christiansen, P Roepstorff… - Microbes and infection, 2000 - Elsevier
The human pathogen Chlamydia trachomatis is an obligate intracellular bacterium,
characterized by a developmental cycle that alternates between the infectious, extracellular
elementary bodies and intracellular, metabolically active reticulate bodies. The cellular
immune effector interferon gamma (IFN-γ) inhibits chlamydial multiplication in human
epithelial cells by induction of the tryptophan degrading enzyme indoleamine 2, 3
dioxygenase. IFN-γ causes persistent C. trachomatis serovar A infections with atypical …
characterized by a developmental cycle that alternates between the infectious, extracellular
elementary bodies and intracellular, metabolically active reticulate bodies. The cellular
immune effector interferon gamma (IFN-γ) inhibits chlamydial multiplication in human
epithelial cells by induction of the tryptophan degrading enzyme indoleamine 2, 3
dioxygenase. IFN-γ causes persistent C. trachomatis serovar A infections with atypical …
