Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production
SH Hefeneider, KA Cornell, LE Brown… - Clinical immunology and …, 1992 - Elsevier
The molecular basis for the cellular interaction of DNA and nucleosomes and the
physiological consequences of this binding were examined. Both DNA and nucleosomes
were demonstrated to bind specifically to the surface of human peripheral blood
mononuclear cells and the murine T cell line S49. Western blots of S49 cell membranes,
using probes of biotin-labeled DNA and nucleosomes, showed reactivity at 29 and 69 kDa.
Functionally, the interaction of DNA and nucleosomes with murine spleen cells stimulated …
physiological consequences of this binding were examined. Both DNA and nucleosomes
were demonstrated to bind specifically to the surface of human peripheral blood
mononuclear cells and the murine T cell line S49. Western blots of S49 cell membranes,
using probes of biotin-labeled DNA and nucleosomes, showed reactivity at 29 and 69 kDa.
Functionally, the interaction of DNA and nucleosomes with murine spleen cells stimulated …
