The presence of spiral-shaped bacteria on human gastric mucosa was first recognized
nearly one hundred years ago (Pel, 1899). These bacteria were isolated for the first time in
1982, in cultures of endoscopic biopsy specimens from patients with gastritis and peptic
ulceration (Marshall, 1983; Warren, 1983). For phenotypic reasons, such as spiral shape,
motility, growth under microaerophilic conditions and isolation from the alimentary tract, the
organism was classified as a member of the genus Campylobacter and was called …

To determine whether infection with a Helicobacter pylori strain possessing cagA is
associated with an increased risk of development of adenocarcinoma of the stomach, we
used a nested case-control study based on a cohort of 5443 Japanese-American men in
Oahu, Hawaii, who had a physical examination and a phlebotomy during 1967 to 1970. We
matched 103 H. pylori-infected men who developed gastric cancer during a 21-year
surveillence period with 103 H. pylori-infected men who did not develop gastric cancer and …