Atorvastatin ameliorates experimental autoimmune neuritis by decreased Th1/Th17 cytokines and up-regulated T regulatory cells
XL Li, YC Dou, Y Liu, CW Shi, LL Cao, XQ Zhang… - Cellular …, 2011 - Elsevier
Statins have anti-inflammatory and immune-regulating properties. To investigate the effects
of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–
Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine
peripheral myelin in complete Freund's adjuvant. We found that atorvastatin ameliorated the
clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ+
and IL-17+ cells in sciatic nerves, decreased the CD80 expression and increased the …
of atorvastatin on experimental autoimmune neuritis (EAN), an animal model of Guillain–
Barré syndrome (GBS), atorvastatin was administered to Lewis rats immunized with bovine
peripheral myelin in complete Freund's adjuvant. We found that atorvastatin ameliorated the
clinical symptoms of EAN, decreased the numbers of inflammatory cells as well as IFN-γ+
and IL-17+ cells in sciatic nerves, decreased the CD80 expression and increased the …