[HTML][HTML] Intramucosal lipomas of the colon implicate Cowden syndrome
A Caliskan, WK Kohlmann, KE Affolter, E Downs-Kelly… - Modern Pathology, 2018 - Elsevier
Intramucosal lipomas are rare and easily overlooked by pathologists, despite their
diagnostic significance for Cowden syndrome (PTEN hamartoma tumor syndrome), an
inherited multiorgan cancer syndrome. Only 25–35% of patients harbor identifiable PTEN
mutations, thus clinical features, like intramucosal lipomas, remain the mainstay of
diagnosis. The significance and diagnostic approach to intramucosal lipomas have not been
thoroughly addressed in the literature. Intramucosal lipomas are mimicked by …
diagnostic significance for Cowden syndrome (PTEN hamartoma tumor syndrome), an
inherited multiorgan cancer syndrome. Only 25–35% of patients harbor identifiable PTEN
mutations, thus clinical features, like intramucosal lipomas, remain the mainstay of
diagnosis. The significance and diagnostic approach to intramucosal lipomas have not been
thoroughly addressed in the literature. Intramucosal lipomas are mimicked by …
