The biogenesis and emerging roles of circular RNAs
LL Chen - Nature reviews Molecular cell biology, 2016 - nature.com
Nature reviews Molecular cell biology, 2016•nature.com
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of
thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels,
recent findings have shed new light on their cell type-specific and tissue-specific expression
and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs
shape gene expression by titrating microRNAs, regulating transcription and interfering with
splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.
thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels,
recent findings have shed new light on their cell type-specific and tissue-specific expression
and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs
shape gene expression by titrating microRNAs, regulating transcription and interfering with
splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.
Abstract
Circular RNAs (circRNAs) are produced from precursor mRNA (pre-mRNA) back-splicing of thousands of genes in eukaryotes. Although circRNAs are generally expressed at low levels, recent findings have shed new light on their cell type-specific and tissue-specific expression and on the regulation of their biogenesis. Furthermore, the data indicate that circRNAs shape gene expression by titrating microRNAs, regulating transcription and interfering with splicing, thus effectively expanding the diversity and complexity of eukaryotic transcriptomes.
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