[HTML][HTML] Retinal pigmented epithelial cells obtained from human induced pluripotent stem cells possess functional visual cycle enzymes in vitro and in vivo
Differentiated retinal pigmented epithelial (RPE) cells have been obtained from human
induced pluripotent stem (hiPS) cells. However, the visual (retinoid) cycle in hiPS-RPE cells
has not been adequately examined. Here we determined the expression of functional visual
cycle enzymes in hiPS-RPE cells compared with that of isolated wild-type mouse primary
RPE (mpRPE) cells in vitro and in vivo. hiPS-RPE cells appeared morphologically similar to
mpRPE cells. Notably, expression of certain visual cycle proteins was maintained during cell …
induced pluripotent stem (hiPS) cells. However, the visual (retinoid) cycle in hiPS-RPE cells
has not been adequately examined. Here we determined the expression of functional visual
cycle enzymes in hiPS-RPE cells compared with that of isolated wild-type mouse primary
RPE (mpRPE) cells in vitro and in vivo. hiPS-RPE cells appeared morphologically similar to
mpRPE cells. Notably, expression of certain visual cycle proteins was maintained during cell …