[HTML][HTML] Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy
CM Li, JB Presley, X Zhang, N Dashti, BH Chung… - Journal of lipid …, 2005 - ASBMB
The principal extracellular lesions of age-related maculopathy (ARM), the leading cause of
vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between
the retinal pigment epithelium (RPE) and its blood supply. With age, 80–100 nm solid
particles containing esterified cholesterol (EC) accumulate in normal BrM, and
apolipoprotein B (apoB) immunoreactivity is detectable in BrM-and ARM-associated lesions.
Yet little evidence indicates that increased plasma cholesterol is a risk factor for ARM. To …
vision loss in the elderly, involve Bruch's membrane (BrM), a thin vascular intima between
the retinal pigment epithelium (RPE) and its blood supply. With age, 80–100 nm solid
particles containing esterified cholesterol (EC) accumulate in normal BrM, and
apolipoprotein B (apoB) immunoreactivity is detectable in BrM-and ARM-associated lesions.
Yet little evidence indicates that increased plasma cholesterol is a risk factor for ARM. To …