[HTML][HTML] Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 …
T Wu, J Tian, RG Cutler, RS Telljohann… - Laboratory …, 2010 - Elsevier
To maintain normal retinal function, retinal pigment epithelial (RPE) cells engulf
photoreceptor outer segments (ROS) enriched in free fatty acids (FFAs). We have previously
demonstrated fatty acid-binding protein 5 (FABP5) downregulation in the RPE/choroidal
complex in a mouse model of aging and early age-related macular degeneration. FABPs are
involved in intracellular transport of FFAs and their targeting to specific metabolic pathways.
To elucidate the role of FABP5 in lipid metabolism, the production of the FABP5 protein in a …
photoreceptor outer segments (ROS) enriched in free fatty acids (FFAs). We have previously
demonstrated fatty acid-binding protein 5 (FABP5) downregulation in the RPE/choroidal
complex in a mouse model of aging and early age-related macular degeneration. FABPs are
involved in intracellular transport of FFAs and their targeting to specific metabolic pathways.
To elucidate the role of FABP5 in lipid metabolism, the production of the FABP5 protein in a …