Highlights•Recent data highlight the true burden of non-primary maternal infection in
congenital CMV infection.•Accurate diagnosis of maternal primary infection is
achievable.•Diagnosis of fetal infection by amniocentesis is reliable.•Establishing the
prognosis of an infected fetus is achievable with over 90% positive and negative predictive
values.•First successful non-randomized study using valaciclovir for symptomatic fetuses.
Cytomegalovirus (CMV) congenital infection affects 0.7% of live births worldwide and is the …