Early antibody response against hypervariable region 1 is associated with acute self-limiting infections of hepatitis C virus
A Zibert, H Meisel, W Kraas, A Schulz, G Jung… - Hepatology, 1997 - journals.lww.com
Antibodies directed to hypervariable region 1 (HVR1) of hepatitis C virus (HCV) have
recently been shown to neutralize the corresponding HCV isolate in vitro. We analyzed the
appearance of antibodies directed to HVR1 during the course of infection in a large group of
patients who have been infected by the same isolate of a HCV contaminated anti-D
immunoglobulin (HCV-AD78). An enzyme-linked immunosorbent assay (ELISA) was
established using a synthetic peptide to detect antibodies against the main HVR1 variant of …
recently been shown to neutralize the corresponding HCV isolate in vitro. We analyzed the
appearance of antibodies directed to HVR1 during the course of infection in a large group of
patients who have been infected by the same isolate of a HCV contaminated anti-D
immunoglobulin (HCV-AD78). An enzyme-linked immunosorbent assay (ELISA) was
established using a synthetic peptide to detect antibodies against the main HVR1 variant of …