Composition of HBsAg is predictive of HBsAg loss during treatment in patients with HBeAg-positive chronic hepatitis B
M Pfefferkorn, T Schott, S Böhm, D Deichsel… - Journal of …, 2021 - Elsevier
Background & Aims During treatment of chronic HBV infections, loss or seroconversion of
the HBV surface antigen (HBsAg) is considered a functional cure. HBsAg consists of the
large (LHBs), middle (MHBs), and small surface protein (SHBs) and their relative proportions
correlate strongly with disease stage. Our aim was to assess the association between
HBsAg composition and functional cure during treatment. Methods A total of 83 patients
were retrospectively analyzed. HBsAg loss was achieved by 17/64 patients during nucleos …
the HBV surface antigen (HBsAg) is considered a functional cure. HBsAg consists of the
large (LHBs), middle (MHBs), and small surface protein (SHBs) and their relative proportions
correlate strongly with disease stage. Our aim was to assess the association between
HBsAg composition and functional cure during treatment. Methods A total of 83 patients
were retrospectively analyzed. HBsAg loss was achieved by 17/64 patients during nucleos …