Anti-NGF therapy profoundly reduces bone cancer pain and the accompanying increase in markers of peripheral and central sensitization
MA Sevcik, JR Ghilardi, CM Peters, TH Lindsay… - Pain, 2005 - Elsevier
Bone cancer pain can be difficult to control, as it appears to be driven simultaneously by
inflammatory, neuropathic and tumorigenic mechanisms. As nerve growth factor (NGF) has
been shown to modulate inflammatory and neuropathic pain states, we focused on a novel
NGF sequestering antibody and demonstrated that two administrations of this therapy in a
mouse model of bone cancer pain produces a profound reduction in both ongoing and
movement-evoked bone cancer pain-related behaviors that was greater than that achieved …
inflammatory, neuropathic and tumorigenic mechanisms. As nerve growth factor (NGF) has
been shown to modulate inflammatory and neuropathic pain states, we focused on a novel
NGF sequestering antibody and demonstrated that two administrations of this therapy in a
mouse model of bone cancer pain produces a profound reduction in both ongoing and
movement-evoked bone cancer pain-related behaviors that was greater than that achieved …
