Identification and functional implication of nuclear localization signals in the N-terminal domain of JMJD5
X Huang, L Zhang, H Qi, J Shao, J Shen - Biochimie, 2013 - Elsevier
JMJD5 has recently been reported to participate in circadian rhythm regulation,
embryological development, osteoclastogenesis and tumorigenesis. Although JMJD5 has
been found mainly localized in the nucleus of cells, how it enters the nucleus remains
unclear. Here we report that JMJD5 contains a functional bipartite nuclear localization signal
(NLS) and a chromosome region maintenance 1 (CRM1)-dependent nuclear export signal
(NES). Importin α/β and transportin-1 were further identified as JMJD5-associated transport …
embryological development, osteoclastogenesis and tumorigenesis. Although JMJD5 has
been found mainly localized in the nucleus of cells, how it enters the nucleus remains
unclear. Here we report that JMJD5 contains a functional bipartite nuclear localization signal
(NLS) and a chromosome region maintenance 1 (CRM1)-dependent nuclear export signal
(NES). Importin α/β and transportin-1 were further identified as JMJD5-associated transport …