[HTML][HTML] JMJD5 (Jumonji domain-containing 5) associates with spindle microtubules and is required for proper mitosis
Z He, J Wu, X Su, Y Zhang, L Pan, H Wei… - Journal of Biological …, 2016 - ASBMB
Precise mitotic spindle assembly is a guarantee of proper chromosome segregation during
mitosis. Chromosome instability caused by disturbed mitosis is one of the major features of
various types of cancer. JMJD5 has been reported to be involved in epigenetic regulation of
gene expression in the nucleus, but little is known about its function in mitotic process. Here
we report the unexpected localization and function of JMJD5 in mitotic progression. JMJD5
partially accumulates on mitotic spindles during mitosis, and depletion of JMJD5 results in …
mitosis. Chromosome instability caused by disturbed mitosis is one of the major features of
various types of cancer. JMJD5 has been reported to be involved in epigenetic regulation of
gene expression in the nucleus, but little is known about its function in mitotic process. Here
we report the unexpected localization and function of JMJD5 in mitotic progression. JMJD5
partially accumulates on mitotic spindles during mitosis, and depletion of JMJD5 results in …