[HTML][HTML] Retinitis pigmentosa GTPase regulator (RPGR)-interacting protein is stably associated with the photoreceptor ciliary axoneme and anchors RPGR to the …
DH Hong, G Yue, M Adamian, T Li - Journal of Biological Chemistry, 2001 - ASBMB
Retinitis pigmentosa (RP) is a blinding retinal disease in which the photoreceptor cells
degenerate. Mutations in the gene for retinitis pigmentosa GTPase regulator (RPGR) are a
frequent cause of RP. The function of RPGR is not well understood, but it is thought to be a
putative guanine nucleotide exchange factor for an unknown G protein. Ablation of the
RPGR gene in mice suggested a role in maintaining the polarized distribution of opsin
across the cilia. To investigate its function, we used a protein interaction screen to identify …
degenerate. Mutations in the gene for retinitis pigmentosa GTPase regulator (RPGR) are a
frequent cause of RP. The function of RPGR is not well understood, but it is thought to be a
putative guanine nucleotide exchange factor for an unknown G protein. Ablation of the
RPGR gene in mice suggested a role in maintaining the polarized distribution of opsin
across the cilia. To investigate its function, we used a protein interaction screen to identify …