Abstract Oral-Facial-Digital type I (OFD1) is a rare inherited form of renal cystic disease
associated with ciliary dysfunction. This disorder is due to mutations in the OFD1 gene that
encodes a protein localized to centrosomes and basal bodies in different cell types.
Immunofluorescence analysis demonstrated that OFD1 displays a dynamic distribution
during cell cycle. High-content microscopy analysis of Ofd1-depleted fibroblasts revealed
impaired cell cycle progression. Immunofluorescence analysis and cell proliferation assays …