[HTML][HTML] Hypoxia-inducible factor-1 deficiency results in dysregulated erythropoiesis signaling and iron homeostasis in mouse development
D Yoon, YD Pastore, V Divoky, E Liu… - Journal of Biological …, 2006 - ASBMB
Hypoxia-inducible factor-1 (HIF-1) regulates the transcription of genes whose products play
critical roles in energy metabolism, erythropoiesis, angiogenesis, and cell survival. Limited
information is available concerning its function in mammalian hematopoiesis. Previous
studies have demonstrated that homozygosity for a targeted null mutation in the Hif1α gene,
which encodes the hypoxia-responsive α subunit of HIF-1, causes cardiac, vascular, and
neural malformations resulting in lethality by embryonic day 10.5 (E10. 5). This study …
critical roles in energy metabolism, erythropoiesis, angiogenesis, and cell survival. Limited
information is available concerning its function in mammalian hematopoiesis. Previous
studies have demonstrated that homozygosity for a targeted null mutation in the Hif1α gene,
which encodes the hypoxia-responsive α subunit of HIF-1, causes cardiac, vascular, and
neural malformations resulting in lethality by embryonic day 10.5 (E10. 5). This study …