[HTML][HTML] DNA methylation-based classification of sinonasal undifferentiated carcinoma
S Dogan, V Vasudevaraja, B Xu, J Serrano… - Modern Pathology, 2019 - Elsevier
Sinonasal undifferentiated carcinoma (SNUC) is an aggressive malignancy harboring IDH2
R172 mutations in> 80% cases. We explored the potential of genome-wide DNA methylation
profiling to elucidate tumor biology and improve the diagnosis of sinonasal undifferentiated
carcinoma and its histologic mimics. Forty-two cases, including sinonasal undifferentiated,
large cell neuroendocrine, small cell neuroendocrine, and SMARCB1-deficient carcinomas
and olfactory neuroblastoma, were profiled by Illumina Infinium Methylation EPIC array …
R172 mutations in> 80% cases. We explored the potential of genome-wide DNA methylation
profiling to elucidate tumor biology and improve the diagnosis of sinonasal undifferentiated
carcinoma and its histologic mimics. Forty-two cases, including sinonasal undifferentiated,
large cell neuroendocrine, small cell neuroendocrine, and SMARCB1-deficient carcinomas
and olfactory neuroblastoma, were profiled by Illumina Infinium Methylation EPIC array …
