[HTML][HTML] CatSperβ, a novel transmembrane protein in the CatSper channel complex
J Liu, J Xia, KH Cho, DE Clapham, D Ren - Journal of Biological Chemistry, 2007 - ASBMB
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell
hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to
form a sperm-specific, alkalinization-activated Ca 2+-selective channel. We set out to identify
proteins associating with CatSper that might help explain its unique role in spermatozoa.
Using a transgenic approach, a CatSper1 complex was purified from mouse testis that
contained heat shock protein 70-2, a testis-specific chaperone, and CatSperβ, a novel …
hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to
form a sperm-specific, alkalinization-activated Ca 2+-selective channel. We set out to identify
proteins associating with CatSper that might help explain its unique role in spermatozoa.
Using a transgenic approach, a CatSper1 complex was purified from mouse testis that
contained heat shock protein 70-2, a testis-specific chaperone, and CatSperβ, a novel …