Direct action of endocrine disrupting chemicals on human sperm
C Schiffer, A Müller, DL Egeberg, L Alvarez… - EMBO …, 2014 - embopress.org
EMBO reports, 2014•embopress.org
Synthetic endocrine disrupting chemicals (EDC s), omnipresent in food, household, and
personal care products, have been implicated in adverse trends in human reproduction,
including infertility and increasing demand for assisted reproduction. Here, we study the
action of 96 ubiquitous EDC s on human sperm. We show that structurally diverse EDC s
activate the sperm‐specific CatSper channel and, thereby, evoke an intracellular Ca2+
increase, a motility response, and acrosomal exocytosis. Moreover, EDC s desensitize …
personal care products, have been implicated in adverse trends in human reproduction,
including infertility and increasing demand for assisted reproduction. Here, we study the
action of 96 ubiquitous EDC s on human sperm. We show that structurally diverse EDC s
activate the sperm‐specific CatSper channel and, thereby, evoke an intracellular Ca2+
increase, a motility response, and acrosomal exocytosis. Moreover, EDC s desensitize …
Abstract
Synthetic endocrine disrupting chemicals (EDCs), omnipresent in food, household, and personal care products, have been implicated in adverse trends in human reproduction, including infertility and increasing demand for assisted reproduction. Here, we study the action of 96 ubiquitous EDCs on human sperm. We show that structurally diverse EDCs activate the sperm‐specific CatSper channel and, thereby, evoke an intracellular Ca2+ increase, a motility response, and acrosomal exocytosis. Moreover, EDCs desensitize sperm for physiological CatSper ligands and cooperate in low‐dose mixtures to elevate Ca2+ levels in sperm. We conclude that EDCs interfere with various sperm functions and, thereby, might impair human fertilization.
embopress.org