Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy
A Ejdesjö, S Brings, T Fleming, RG Fred… - Reproductive …, 2016 - Elsevier
Abstract The receptor for Advanced Glycation End products (RAGE) is implicated in the
pathogenesis of diabetic complications, but its importance in diabetic embryopathy is
unclear. We therefore investigated the role of RAGE in diabetic embryopathy using
streptozotocin induced diabetes in female wild type (WT) C57Bl/6N and RAGE knockout
C57Bl/6N (RAGE−/−) mice, mated with control males of the same genotype. Maternal
diabetes induced more fetal resorption and malformation (facial skeleton, neural tube) in the …
pathogenesis of diabetic complications, but its importance in diabetic embryopathy is
unclear. We therefore investigated the role of RAGE in diabetic embryopathy using
streptozotocin induced diabetes in female wild type (WT) C57Bl/6N and RAGE knockout
C57Bl/6N (RAGE−/−) mice, mated with control males of the same genotype. Maternal
diabetes induced more fetal resorption and malformation (facial skeleton, neural tube) in the …