Role of the hematopoietic stem cells in immunological memory
V Govindarajah, D Reynaud - Current stem cell reports, 2022 - Springer
V Govindarajah, D Reynaud
Current stem cell reports, 2022•SpringerAbstract Purpose of Review Immunological memory is an important evolutionary adaptation
of the immune system. Previously restricted to the adaptive immune system, the concept of
memory has recently been broadened to the innate immune system. This review
summarizes recent studies that highlight the contribution of the hematopoietic stem cells
(HSCs) in supporting immunological memory. Recent Findings Short-lived innate immune
cells can build a long-lasting memory of infection to improve their response to secondary …
of the immune system. Previously restricted to the adaptive immune system, the concept of
memory has recently been broadened to the innate immune system. This review
summarizes recent studies that highlight the contribution of the hematopoietic stem cells
(HSCs) in supporting immunological memory. Recent Findings Short-lived innate immune
cells can build a long-lasting memory of infection to improve their response to secondary …
Purpose of Review
Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune system, the concept of memory has recently been broadened to the innate immune system. This review summarizes recent studies that highlight the contribution of the hematopoietic stem cells (HSCs) in supporting immunological memory.
Recent Findings
Short-lived innate immune cells can build a long-lasting memory of infection to improve their response to secondary challenges. Studies show that these unexpected properties of the innate immune system are sustained by epigenetic and metabolic changes in the HSC compartment.
Summary
HSCs are durably altered in response to pathogens and serve as long-term support for innate immune memory. Many questions remain regarding the mechanisms contributing to the induction and the maintenance of this immune memory in HSCs. Answering these questions will open new perspectives to understand how environmental factors shape the HSC activity over time.
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