[HTML][HTML] Alterations of gut microbiota in patients with irritable bowel syndrome based on 16S rRNA-targeted sequencing: a systematic review

R Duan, S Zhu, B Wang, L Duan - Clinical and translational …, 2019 - journals.lww.com
METHODS: The databases PubMed, Cochrane Library, Web of Science, and Embase were
searched for studies published until February 28, 2018, for case–control studies detecting
gut microbiota in patients with IBS. Methodological quality was assessed using the
Newcastle–Ottawa Scale. The α-diversity and alterations of gut microbiota in patients with
IBS compared with HCs were analyzed. RESULTS: Sixteen articles involving 777 patients
with IBS and 461 HCs were included. Quality assessment scores of the studies ranged from …